Prof. Vijay Dhawan, The Feinstein Institute for Medical Research: Blood brain barrier permeability in Parkinson’s disease subjects with levodopa induced dyskinesia evaluated with 82Rb/PET brain imaging
Prof. Vijay Dhawan, PhD
The Feinstein Institute for Medical Research
Blood brain barrier permeability in Parkinson’s disease subjects with levodopa induced dyskinesia evaluated with 82Rb/PET brain imaging
Povzetek / Abstract:
Background: The pathophysiology of dyskinesia in Parkinson’s disease (PD) is not yet fully understood. Recent studies on a rodent model have raised the possibility of increased blood–brain barrier (BBB) permeability.
Objective: We examined the hypothesis that levodopa induced dyskinesia are caused by increased BBB permeability in PD patients.
Methods: We used rubidium-82 (82Rb) and PET to quantify BBB influx in vivo in 19 patients with PD, including eight with dyskinesia, and 12 age- and sex-matched healthy subjects.
Results: Rubidium influx into brain tissue was undetectable in PD patients with or without levodopa-induced dyskinesia, scanned both on and off drug.
Conclusions: Our findings do not support increased BBB permeability in PD patients with or without dyskinesia.
