Dr. Jošt Stergar (FMF): Multi-scale imaging in biology and medicine

Multi-scale imaging is based on acquisition and coupled analysis of imaging data obtained through multiple imaging techniques, operating at different length-scales, ranging from microscopy to macroscopic imaging. For a successful multi-scale analysis, the additional insight into the samples beyond the imaging resolution is required. This can be achieved through the use of advanced imaging modalities such as hyperspectral imaging and optical coherence tomography. The main benefit of multi-scale imaging is an improved insight into the relationships between macroscopic indicative changes in tissues with the underlying microscopic changes that accompany the onset and progression of a disease. This translation requres identification of metrices on all the examined length scales and subsequent propagation through either statistical analysis or more rigorous multi-scale modelling. A wholesome approach to multi-scale imaging requires both appropriate instrumentation as well as calibration and verification with standardized samples. In the introductory part of the seminar, I will present the the concept of multi-scale imaging, development and characterization of multiple imaging systems, and an application of multi-scale analysis to tissue-mimicking phantoms.
The main part of the seminar will be dedicated to biomedical applications of multi-scale imaging, where it promises to offer both improved and more personalized diagnostics along with improved insights into the onset and development of various pathologies. On the microscopic scale, a key stepping-stone in developing robust mutli-scale analysis is the research and development of novel methods for quantitative digital pathology, which enable coupled analysis across length scales that shed light onto correlations and causality of indicative macroscopic metrices. On the macroscopic scale, hyperspectral imaging and optical coherence tomography provide metrices that are indicative of underlying changes, such as changes in light scattering and absorption, corresponding to morphological and physiological changes in the affected tissues. In the scope of this seminar I will present some recent advances and results from the field of multi-scale imaging in preclinical studies as well as the vision for the future of multi-scale imaging in biomedicine and further.
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