Assist. Prof. Wojciech Zbijewski (Johns Hopkins U): New X-ray-based technologies for quantitative medical imaging
X-ray-based imaging modalities - radiography, tomosynthesis, conventional multi-detector CT (MDCT), and point-of-care cone-beam CT (CBCT) - are the mainstays of modern radiology. Traditionally, they are primarily used for pathology detection rather than quantification. The talk will cover the development of new quantitative capabilities for x-ray imaging, in particular for applications in orthopedics. The focus will be on the physics of scanner hardware, acquisition protocols, and image formation algorithms. Topics will include CMOS flat-panel detector optimization for in vivo ultra-high resolution CBCT of trabecular bone, model-based reconstruction for Dual Energy bone composition imaging using multi-source CBCT and robotic CBCT, and the use of statistical shape models as priors to obtain morphological measurements from limited tomosynthesis datasets. The presentation will illustrate how quantitative imaging tasks can be used to motivate new imaging technologies and how quantitative imaging-specific figures of merit can be incorporated into the design of x-ray-based systems and algorithms.