Radiobiology

Regular enrolement

Cell proliferation and tumor growth characteristics: kinetics of cellular and tumor growth, factors that affect tumor growth, test of tumor growth.
Cell proliferation and organization of normal tissues: organization of normal tissues depending on cell proliferation and with it connect radiation response
Radiation effects on cells: reproductive cell death concepts, cell clonogenity, cell survival curves, models of cell survival curves, DNA damage and damage of other organels, genetic control of the cellular response to radiation
Response and normal tissue tolerance: normal tissue radiation damage assessment approaches, functional tests and clonogen survival tests, early and late tissue toxicity
Tumor radiobiology: approaches to evaluate anti-tumor effects in vivo
Radiosensitivity of cells: dependence on cell cycle, proliferative potential, cell differentiality and radiation damage repair

• E.J.Hall: Radiobiology for the Radiologist, Lippincott Williams and Wikins Publishers; 5th edition, 588 pp.. ISBN: 0781726492
• I.F. Tannock in R.P. Hill: The Basic Science of Oncology, McGraw Hill, 3rd edition, 539 pp. ISBN 0071054847
• G.G. Steel: Basic Clinical Radiobiology, Edward Arnold, 3rd edition, 280 pp. ISBN: 0340807830

Students get familiar with the theoretical basis of radiobiology that lead to more effective radiation therapy.

Competences:
Understanding of the specific biological properties of tumor cells and tumors. Understanding of the radiation effects on different biological systems, from the molecular to organ level. Understanding of the basic biological principles of the combined therapies – radiosensitivity and radioprotection.

Knowledge and understanding:
Understanding fundamental concepts of basic and clinical radiobiology.

Application:
Use of the radiobiology knowlege for recognision and solving of the problems in radiation therapy.

Reflection:
Critical evaluation of the fundamental knowledge of basic and clinical radiobiology in radiotherapy and diagnostic radiology.

Transferable skills:
Ability to understand biomedical fields related to ionizing radiation and ability to effectively communicate with the experts from these fields.

Lectures, seminars, consultations.

Oral exam
Seminar
grading: 5 (fail), 6-10 (pass) (according to the Statute of UL)

1. Savarin M, Znidar K, Sersa G, Komel T, Cemazar M, Kamensek U. Tumor radiosensitization by gene electrotransfer-mediated double targeting in tumor vasculature. Int J Mol Sci 2023; 24: 2755.
2. Remic T, Sersa G, Levpuscek K, Lampreht Tratar U, Ursic Valentinuzzi K, Coer A, Kamensek U. Tumor cell-based vaccine contributes to local tumor irradiation by eliciting a tumor model-dependent systemic immune response. Front Immunol 2022; 13: 974912.
3. Todorovic V, Groselj B, Cemazar M, Prevc A, Zakelj MN, Strojan P, Sersa G. Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity. Radiol Oncol 2022; 56: 173-84.