Physics of functional and molecular imaging *

Regular enrolement

Basics of nuclear medicine: purpose, principles and basic concepts (scintigraphy, PET, SPECT, Compton camera), radioisotopes and radiotracers, interaction of gamma rays with matter
Radioisotope production: nuclear reactors, cyclotrons, radioisotope generators, radiopharmaceutical production, quality assurance
Dosimetry: internal and external dosimetry, system MIRD, kinetic models, Monte Carlo dosimetry
Detectors for nuclear medicine: required characteristics (gain, positional, temporal, energy resolution, geometrical acceptance), types of detectors (scintillation, semiconductor, gas), types of scintillators, whole body counters
Gamma camera: fundamental principles, components (scintillator, electronics, collimator), types, characteristics (positional resolution, gain, energy resolution, count dednsity), gamma camera limitations (non-uniformity and non-linearity, correlations), characteristics of different collimators, measurements of gamma camera characteristics, clinical application.
Image quality: spatial resolution, contrast, noise, methods for image quality evaluation.
Image reconstruction methods: Fourier-based deconvolution methods, iterative methods, comparison between the methods.
SPECT: different types of SPECT scanners, attenuation effect and its correlations, scatter correction, partial volume correction, image characteristics (resolution, linearity, noise), clinical use.
PET: fundamental principles, factors that impact image quality (positron range, co-linearity of photons, scatter, random coincidences, reconstruction filters), types of PET cameras, data acquisition in 2D and 3D, image reconstruction and image corrections (filters, random coincidences, scatter, attenuation), SUV calculation, clinical use, PET/CT
Digital image processing: basics, image visualization, filtering, smoothing, edge detection, active contours

• Simon R. Cherry, James A. Sorenson, Michael E. Phelps, Physics in nuclear medicine, W B Saunders; 3rd edition (July 18, 2003), 523 pp. ISBN: 072168341X
• Paul J. Early, D. Bruce Sodee, Principles and practice of nuclear medicine, Mosby; 2nd edition (January 15, 1995), 877 pp. ISBN: 0801625777

Students get familiar with the fundamentals of functional and molecular imaging; methods, scanners, detectors, image reconstruction and elements that determine image quality.
Competences: Understanding of the physical fundamentals of different nuclear medicine techniques and image reconstruction. Understanding of factors that influence image quality. Obtaining basic practical knowledge working with diagnostic equipment and understanding of potential work hazards. Obtaining basic knowledge of digital imaging analysis.

Knowledge and understanding:
Obtaining fundamental knowledge of different procedures in nuclear medicine. Understanding the role of detectors and image reconstruction algorithms.
Understanding methods for radioisotope production.
Application:
Fundamental knowledge of physica principles underlying SPECT and PET imaging in combination with other imaging methods.
Reflection:
Critical evaluation of the theoretical predictions with the experimental results of radioisotope production in tissue.
Transferable skills:
Ability to collect the data and critically evaluate new literature in the field of functional and molecular imaging. Ability to communicate with experts from similar fields, particularly medical field.

Lectures, problem solving, homework, consultations.

Written exam (theory)
Written exam (problem solving), homework
Subject is also a part of the final committee exam. Marks: pass/fail (according to the UL rules).
grading: 5 (fail), 6-10 (pass) (according to the Statute of UL)

- VALENTINUZZI, Damijan, VRANKAR, Martina, BOC, Nina, AHAC, Valentina, ZUPANČIČ, Žiga, UNK, Mojca, ŠKALIČ, Katja, ŽAGAR, Ivana, STUDEN, Andrej, SIMONČIČ, Urban, EICKHOFF, Jens C., JERAJ, Robert. [18F]FDG PET immunotherapy radiomics signature (iRADIOMICS) predicts response of non-small-cell lung cancer patients treated with pembrolizumab. Radiology and oncology. [Print ed.]. 2020, vol. 54, no. 3, str. 285-294, iv, ilustr. ISSN 1318-2099. DOI: 10.2478/raon-2020-0042. [COBISS-SI-ID 24723203],

- SCARPELLI, Matthew, SIMONČIČ, Urban, PERLMAN, Scott, LIU, Glenn, JERAJ, Robert. Dynamic 18F-FLT PET imaging of spatiotemporal changes in tumor cell proliferation and vasculature reveals the mechanistic actions of anti-angiogenic therapy. Physics in Medicine & Biology. 2018, vol. 63, art. no. 155008, 14 str., ilustr. ISSN 0031-9155. DOI: 10.1088/1361-6560/aad1be. [COBISS-SI-ID 3223140],

- SIMONČIČ, Urban, LEIBFARTH, Sara, WELZ, Stefan, SCHWENZER, Nina, SCHMIDT, Holger, REISCHL, Gerald, PFANNENBERG, Christina, LA FOUGÈRE, Christian, NIKOLAU, Konstantin, ZIPS, Daniel, THORWARTH, Daniela. Comparison of DCE-MRI kinetic parameters and FMISO-PET uptake parameters in head and neck cancer patients. Medical physics. [Print ed.]. 2017, vol. 44, no. 6, str. 2358-2368. ISSN 0094-2405. DOI: 10.1002/mp.12228. [COBISS-SI-ID 30407975],

- LEIBFARTH, Sara, SIMONČIČ, Urban, MÖNNICH, David, WELZ, Stefan, SCHMIDT, Holger, SCHWENZER, Nina, ZIPS, Daniel, THORWARTH, Daniela. Analysis of pairwise correlations in multi-parametric PET/MR data for biological tumor characterization and treatment individualization strategies. European journal of nuclear medicine and molecular imaging. [Print ed.]. 2016, vol. 43, no. 7, str. 1199-1208. ISSN 1619-7070. DOI: 10.1007/s00259-016-3307-7. [COBISS-SI-ID 29390631],